Figure 1

Comparison of the variation in the methylation of probes in the region between +2,000 and −2,000. Probes related to the immune-inflammatory genes (n = 5422), cell cycle (n = 4538), and stably expressed genes (n = 2349). Note that the frequency of probes with decreased methylation in periodontitis was higher in genes related to the immune system process (chi-squared test, p < 2.2e − 16).