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Table 3 Genes positively associated with schizophrenia where methylation changed in response to olanzapine

From: The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

Genea Reference (PubMedID) Affected in Peak length (bp) Peak to transcription start site (bp) Promoter class
Nos1 20645313 Hippocampus 334 -3,719 LCP
Map6 16624526 Hippocampus 169 -2,382 ICP
Drd5 11304828 Hippocampus 844 41 HCP
Cacna1c 23183239 Hippocampus 425 -3,692 LCP
Bdnf 16818862 Hippocampus 329 -492 ICP
Gsksb 18500637 Hippocampus 573 -1,042 HCP
Tf 18045615 Hippocampus 159 -3,020 LCP
Cnp 16389193 Hippocampus 464 1,198 HCP
Amacr 20875727 Hippocampus 558 164 HCP
Psen2 19232479 Hippocampus 249 620 LCP
Pax6 10376119 Hippocampus 341 326 ICP
Dlx1 18384059 Hippocampus 431 -2,043 HCP
Dlx1 18384059 Cerebellum 1,330 257 HCP
Cnp 16389193 Cerebellum 769 940 HCP
Psen2 19232479 Cerebellum 455 442 LCP
Pax6 10376119 Cerebellum 349 -3,481 ICP
Stx1a 15219469 Cerebellum 149 72 HCP
Drd5 11304828 Cerebellum 264 -169 HCP
Mmp9 20037727 Cerebellum 138 -325 LCP
Tnf 11244489 Cerebellum 269 49 LCP
Grin1 12679240 Cerebellum 264 -1,595 HCP
Tf 18045615 Cerebellum 749 -1,704 LCP
Dlg4 21151988 Cerebellum 134 -1,459 LCP
Amacr 20875727 Cerebellum 138 -48 HCP
Dao 19685198 Cerebellum 287 -2,385 LCP
Dlx1 18384059 Liver 171 -2,993 HCP
Cnp 16389193 Liver 644 -2,644 HCP
Sod2 15193990 Liver 550 594 HCP
Drd5 11304828 Liver 369 -316 HCP
Il6 20393813 Liver 789 -3,030 LCP
Comt 11381111 Liver 638 -3,542 HCP
Apoe 14674716 Liver 2,158 -1,223 LCP
Drd2 18829695 Liver 257 -91 HCP
Nos1 20645313 Liver 348 172 LCP
Drd1 20127886 Liver 540 739 LCP
  1. aAll genes except Nos1, Map6, Il6 and Comt had increased methylation in olanzapine-treated rats.
  2. HCP, high CpG contents; ICP, intermediate CpG contents; LCP, low CpG contents.