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Table 1 Top pathways and associated networks identified by pathway analysis for the hippocampus following olanzapine treatment

From: The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

(a) Top canonical pathways (Genes with increased methylation) P- value No of moleculesa
Dopamine-DARPP32 feedback in cAMP signalling 1.65 × 10–3 20/157 (0.127)
CD27 signalling in lymphocytes 2.42 × 10–4 11/54 (0.204)
Oestrogen-mediated S-phase entry 2.56 × 10–3 6/26 (0.231)
Role of JAK2 in hormone-like cytokine signalling 3.38 × 10–3 7/34 (0.206)
Associated network functions   
Metabolic disease, endocrine system and developmental disorders 35
Cell cycle, cellular growth and proliferation, cell death 24
Molecular transport, neurological disease, cell-to-cell signalling 10
(b) Top canonical pathways (Genes with decreased methylation) P- value No of molecules
CDC42 signalling 2.52 × 10–3 11/131 (0.084)
Prostanoid biosynthesis 2.55 × 10–3 3/9 (0.333)
Calcium signalling 5.92 × 10–3 12/178 (0.067)
D-myo-inositol (1,3,4,5,6)-tetrakisphosphatebiosynthesis 6.18 × 10–3 8/48 (0.167)
Associated network functions  
Developmental disorder, cell death and survival, cellular development 12
Molecular transport, nervous system development and function 10
Carbohydrate metabolism, cell morphology, lipid metabolism 9
Cellular development, skeletal, muscular and cardiovascular system development and function 8
  1. aFor the top canonical pathways, the ratio is the number of molecules in a given pathway that meet the cut-off (P ≤ 0.01) divided by the total number of molecules in the pathway.