LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes

Table 3 Logistic regression analysis evaluating the association between LINE-1 methylation level ( LINE-1 %meth) quartiles and metabolic syndrome (MetS) risk

*LINE-1*%meth quartiles	MetS-,n = 98	MetS+,n = 86	Wald’sχ² = 12.3,P = 0.007^a, OR (95% CL)	P value
Q1: 67.3% to 73.8%	21 (0.22)	25 (0.29)	4.37 (1.59 to 12.02)	0.004
Q2: 73.8% to 75.0%	19 (0.19)	27 (0.31)	4.76 (1.76 to 12.90)	0.002
Q3: 75.0% to 77.3%	28 (0.29)	18 (0.21)	1.82 (0.70 to 4.71)	0.22
Q4: 77.3% to 85.0%	30 (0.31)	16 (0.18)	1.00	-

Odds ratios and P values computed by the logistic regression analysis were obtained while including potential confounding factors in the model, namely age, sex and smoking. The fourth LINE-1%meth quartile (Q4) was set as the reference group.
^aCorresponds to the Wald’s χ² and P value for the effect of LINE-1%meth quartiles. For the whole model, Wald’s χ² = 14.0 and P value = 0.03.
CL = Wald’s confidence limits.