Table 2 List of genes in which altered expression can lead to epigenetic deregulation in MPNs

10–11 translocation-2

TET2

ET, PV, PMF, MF-BP

Hussein et al. (2010); Schaub et al. (2010); Tefferi et al. (2009b)

Additional sex combs like 1

ASXL1

ET, PMF, MF-BP

Carbuccia et al. (2009)

Enhancer of zeste homolog 2

EZH2

MDS/MPN, PMF, MF-BP

Ernst et al. (2010)

Isocitrate dehydrogenase 1 and 2

IDH1/2

ET, PV, PMF, MF-BP

Green and Beer (2010); Pardanani et al. (2010c); Tefferi et al. (2010)

Ikaros family zinc finger 1

IKZF1

MF-BP

Jager et al. (2010)

Janus-associated kinase 2

JAK2V617F

ET, PV, PMF, MF-BP

Nischal et al. (2010); Dawson et al. (2009)

Protein arginine methyltransferase 5

PRMT5

PV

Liu et al. (2011)