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Table 1 Procedure of allogeneic stem cell transplantation: main phases and principles

From: Epigenetic approaches in stem cell transplantation

Procedure/phase Principle
1 Conditioning regimen
  a) Cytoreductive chemotherapy Disease control
Reduction of tumour burden
Induction of remission
  b) Myeloablation/immunoablation Elimination of the immune system of the recipient by (high-dose) chemotherapy or irradiation
2 Stem cell transfusion Donation of “the new” immunosystem
3 Immunosuppression Prevention and treatment of graft rejection and graft-versus-host disease
4 Alloreactivity as further medicinal intervention: maintenance and relapse therapy Elimination of residual malignant cells by the graft-versus-leukaemia reaction, enhancement of the immunotherapeutic effect by donor lymphocyte infusions