Fig. 3
From: Insufficient DNA methylation affects healthy aging and promotes age-related health problems
Histological comparisons of the liver from Dnmt1+/+ and Dnmt1+/− mice at 22 months of age assessed by H&E staining. The histological structure of the liver from Dnmt1+/+ mice (left) is clear and the solid line represents normal central vein in hepatic lobule. The structure of the hepatic lobule from Dnmt1+/− mice (right) was destructed by invasive tumor. Dotted lines indicate representative necrosis area and small arrowheads point to tumor bulks in the liver. Representative pictures were taken using a Nikon Eclipse E400 inverted microscope and DXM1200 digital camera