miRNA | Confirmed target | Mechanism of drug resistance | Chemotherapeutic drug | References |
---|---|---|---|---|
let-7 | CASP3; ESR1; HMGA2; RAS | 2; 3; 5 | Cisplatin; cyclophophamide; doxorubicin; doxorubicin+verapamil; fulvestrant | Chen et al. (2010); Kovalchuk et al. (2008); Salter et al. (2008); Xin et al. (2009) |
miR-7 | EGFR; MRP1 | 1; 5 | Cisplatin; VP-16 | |
miR-9 | CDH1; SIRT1 | 3, 4 | VP-16 | Liang et al. 2010 |
miR-10 | HOXD10 | 2, 3 | Cisplatin, doxorubicin; doxorubicin+verapamil | Chen et al. (2010); Kovalchuk et al. (2008); Pogribny et al. (2010) |
miR-15 | BCL2; CCNE1; FGF7; WNT3A | 3, 4 | Doxorubicin; taxol | |
miR-16 | BCL2; CCND1 | 2 | Docetaxel; doxorubicin; doxorubicin+verapamil; taxol | Kastl et al. (2011); Kovalchuk et al. (2008); Zhou et al. 2010 |
mir-17 | AIB1; BRCA1; E2F1; CCND1; RBl2 | 2; 5 | Cyclophosphamide; doxorubicin; VP-16 | Kovalchuk et al. (2008); Liang et al. (2010); Salter et al. (2008) |
miR-19 | ESR1; CCDN1; PTEN; SOCS1; TNF | 2; 3; 5 | Doxorubicin + verapamil | Chen et al. (2010) |
miR-20 | CDKN1A; E2F1; HIF-1α; RBL2; STAT3; VEGF | 2; 3 | Doxorubicin; taxol | |
miR-21 | BCL2; CDC25; hMSH2; hMSH6; MASPIN; PDCD4; PTEN; RECK; RASGRP1; TIMP3; TPM1 | 2; 3 | Doxorubicin; doxorubicin + verapamil; taxol | Chen et al. (2010); Kovalchuk et al. (2008); Mei et al. (2010) |
miR-22 | ESR1; PTEN | 2; 5 | Doxorubicin | Kovalchuk et al. (2008) |
miR-23 | PTEN | 2 | VP-16 | Liang et al. (2010) |
miR-27 | CYPB1 | 1 | Doxorubicin; taxol | |
miR-28 | BRCA1 | 2 | Doxorubicin | Kovalchuk et al. (2008) |
miR-29 | ADAM12; ADAMTS9; ADAMTS13; DNMT1; DNMT3A; DNMT3B; CDC42; CDK6; ITGA11 | 2, 3, 5 | Cisplatin; doxorubicin; taxol; VP-16 | Kovalchuk et al. (2008); Liang et al. (2010); Pogribny et al. (2010); Zhou et al. (2010) |
miR-30 | CTGF | 3 | Docetaxel; taxol | |
miR-31 | FZD3, ITGA5, M-RIP, MMP16, RDX, RHOA | 3 | Doxorubicin; doxorubicin + verapamil | |
miR-32 | PCAF | 5 | Doxorubicin + verapamil | Chen et al. (2010) |
miR-34 | BCL2; BIRC3; CCDN1; CCNE, CDK4; CDK6; E2F3, MET | 2; 3 | Docetaxel; doxorubicin; doxorubicin+verapamil | Chen et al. (2010); Kastl et al. (2011); Kovalchuk et al. (2008) |
miR-93 | E2F1; FUS1 | 2 | Doxorubicin | Kovalchuk et al. (2008) |
miR-100 | ATM; PlK1 | 2; 3 | Doxorubicin; doxorubicin + verapamil; taxol | Chen et al. (2010); Kovalchuk et al. (2008); Zhao et al. (2008) |
miR-101 | ATM; ESR1; EZH2 | 2; 4; 5 | Tamoxifen | Sachdeva et al. (2011) |
miR-106 | AIB1; BRMS1; E2F1; P21; RB1 | 2; 3; 5 | Doxorubicin; taxol | |
miR-107 | CDK6 | 2 | Doxorubicin | Kovalchuk et al. (2008) |
miR-125 | BAK1; CYP24; HER2/3; P53 | 1; 2 | Docetaxel; doxorubicin; taxol | Kastl et al. (2011); Kovalchuk et al. (2008); Zhou et al. (2010) |
miR-126 | IRS1; P38 | 2; 3 | Docetaxel; cisplatin | |
miR-127 | BCL6 | 2 | Cisplatin; doxorubicin | Pogribny et al. (2010); Kovalchuk et al. (2008); Saito et al. (2006) |
miR-128 | TGFBRI | 3 | Doxorubicin + verapamil; letrozole | |
miR-132 | MECP2; MMP9 | 3; 4 | Cisplatin; doxorubicin | |
miR-140 | HDAC4 | 4 | Doxorubicin; taxol | |
miR-141 | APC; hMSH2; ZEB1 | 2; 3 | Cisplatin; docetaxel; doxorubicin | Kastl et al. (2011); Kovalchuk et al. (2008); Pogribny et al. (2010) |
miR-145 | ESR1; IGFR; IRS1; MUC1; RTNK; SOX2 | 2; 3 | Doxorubicin + verapamil | Chen et al. (2010) |
miR146 | BRCA1 | 2 | Cisplatin; doxorubicin + verapamil; taxol | Chen et al. (2010); Pogribny et al. (2010); Zhou et al. (2010) |
miR-148 | DNMT1; DNMT3B; MSK1 | 3; 4 | Doxrubicin + verapamil; doxorubicin | |
miR-152 | DNMT1 | 4 | Doxorubicin | Kovalchuk et al. (2008) |
miR-155 | FOXO3; RHOA | 2; 3 | Doxorubicin | Kovalchuk et al. (2008) |
miR-181 | ATM; BCL2; HOXA11; PCAF; SIRT1; TIMP3 | 2; 3; 4 | Doxorubicin; doxorubicin + verapamil; fulvestrant; | Chen et al. (2010); Kovalchuk et al. (2008); Xin et al. (2009) |
miR-182 | BRCA1 | 2 | Doxorubicin | Kovalchuk et al. (2008) |
miR-194 | CDH2; DNMT3A; HBEGF; MDM2; MECP2; RAC1; SOCS2 | 2; 3; 4 | Cisplatin; doxorubicin | |
miR-196 | ANXA1 | 3 | Doxorubicin + verapamil | Chen et al. (2010) |
miR-196 | ANXA1; HOXB8 | 3 | Cisplatin | Pogribny et al. (2010) |
miR-199 | DYRK1A; SIRT1 | 2; 4 | Doxorubicin; fulvestrant | |
miR-200 | CTNNB1; MSN; WASF3; ZEB1; ZEB2 | 3 | Actinomycin D; cisplatin; doxorubicin; doxorubicin + verapamil; epothilone B; paclitaxel; vincristine | Chen et al. (2010); Cochrane et al. (2009); Kovalchuk et al. (2008); Pogribny et al. (2010) |
miR-204 | SIRT1 | 4 | Fulvestrant | Xin et al. (2009) |
miR-205 | E2F1; HER3; PTEN; VEGFA; ZEB1; ZEB2 | 2; 3; 5 | Cisplatin; doxorubicin; gefitinib; lapatinib | Iorio et al. (2009); Kovalchuk et al. (2008); Pogribny et al. (2010) |
miR-206 | ESR1; GJA1; HGFR; IGF1; NOTCH3 | 2; 3; 5 | Cisplatin, doxorubicin; doxorubicin + verapamil | Chen et al. (2010); Kovalchuk et al. (2008); Pogribny et al. (2010) |
miR-211 | TGFBR2 | 3 | Fulvestrant | Xin et al. (2009) |
miR-212 | PED; MECP2; MMP9 | 2; 4; 5 | Doxorubicin; fulvestrant | |
miR-214 | ING4; LF; PLXNB1; PTEN | 2 | Cisplatin; doxorubicin | |
miR-216 | PTEN | 2 | Fulvestrant | Xin et al. (2009) |
miR-221/222 | BMF; ESR1; FOXO3; P27; P57; PTEN | 2; 3; 5 | Cisplatin; doxorubicin; doxorubicin + verapamil; fulvestrant; tamoxifen | Chen et al. (2010); Kovalchuk et al. (2008); Miller et al. (2008); Pogribny et al. (2010); Rao et al. (2011); Xin et al. (2009); Zhao et al. (2008) |
miR-224 | CDC42 | 2 | Doxorubicin | Kovalchuk et al. (2008) |
miR-326 | MRP1 | 1 | Doxorubicin; VP-16 | |
miR-328 | BCRP | 1 | Fulvestrant; mitoxantrone | |
miR-331 | E2F1; HER2 | 2; 5 | Doxorubicin | Kovalchuk et al. (2008) |
miR-342 | JMJD (putative) | 4 | Cisplatin; doxorubicin | |
miR-345 | MRP1 | 1 | Cisplatin; doxorubicin | |
miR-346 | NRIP1 | 2 | Fulvestrant | Xin et al. (2009) |
miR-373/520 | RAD23B (putative) | 2 | Fulvestrant | Xin et al. (2009) |
miR-375 | MTPN; RASD5; JAK2; 14-3-3zeta; PDK1 | 2 | Doxorubicin | Kovalchuk et al. (2008) |
miR-429 | ZEB1 | 3 | Cisplatin; docetaxel; doxorubicin + verapamil; VP-16 | Chen et al. (2010); Kastl et al. (2011); Liang et al. (2010); Pogribny et al. (2010) |
miR-451 | MDR1 | 1 | Doxorubicin | Kovalchuk et al. (2008) |
miR-489 | MRP2 (putative) | 1 | Cisplatin; doxorubicin |