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Table 2 Interspersed repetitive sequence hypomethylation and cellular, molecular phenotype

From: Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications

Cancer IRS Cellular phenotype Molecular association Reference
Higher clinical stage Poorer histological grade Survival
Cervical cancer L1 NR PE NR NR Shuangshoti et al. (2007)
Cholangiocarcinoma L1 NR PE NR PE for CIMP and TSG mutation Kim et al. (2009a)
Colorectal cancer L1 NR PE NR NR Chalitchagorn et al. (2004)
L1 NR NR NR PE for MSS Matsuzaki et al. (2005)
L1 NR NR NR PE for MSI and CIN Deng et al. (2006)
L1 NR NR NR NE for MSI Estecio et al. (2007)
L1 PE PE in mucinous histology NR NE for MSI and TSG mutation Iacopetta et al. (2007)
L1 NR NR NR NE for MSI and CIMP Ogino et al. (2008a)
PE for chromosomal alteration in non-MSI tumor
L1 NR NR PE NR Ogino et al. (2008b)
L1 NR NR NR NE for SNPSs in one-carbon pathway genes. Hazra et al. (2010)
L1 NR NR NR LINE-1 methylation level correlated between synchronous cancer pairs from the same individuals. Nosho et al. (2009a)
L1 NR NR NR NE for DNMT3B- positive tumors Nosho et al. (2009b)
L1 NR NR NR PE for CIMP An et al. (2010)
L1 NR NR PE in proximal colon cancer NE in distal colon cancer NR Ahn et al. (2010)
L1 NR NR PE PE for MSI, CIMP, CIN, TSG mutation and TSG expression Baba et al. (2010)
L1 NR NR NR NE for MSI and methylation index Goel et al. (2010)
PE for MSS HNPCC
L1 NR PE NR NR Ibrahim et al. (2011)
L1 NR NR PE NE for MSI and CIMP Kawakami et al. (2011)
Alu, L1 NE PE NR NR Kwon et al. (2010)
Ependymoma Alu NR PE NR NR Xie et al. (2010)
Gastric cancer Alu NR PE NR NR Park et al. (2009)
L1 NR PE NR NR Park et al. (2009)
L1 NR NR NR PE for folate metabolizing gene polymorphisms Hou et al. (2010)
Gastrointestinal stromal cancer L1 PE NR NR NR Igarashi et al. (2010)
Head and neck cancer L1 PE NR NR NR Smith et al. (2007)
L1 NR NR PE especially HPV 16 negative SCC NR Furniss et al. (2008)
L1 NS NS NR NR Subbalekha et al. (2009)
Hepatocellular carcinoma L1 PE PE NR NR Tangkijvanich et al. (2007)
Alu NE PE NR NR Lee et al. (2009)
L1 PE PE NR NR Lee et al. (2009)
L1 NR PE NR NR Kim et al. (2009b)
L1 NR NR PE NR Formeister et al. (2010)
Multiple myeloma (MM) Alu NR PE NR NE for hyperdiploid MM Bollati et al. (2009)
L1 NR PE NR PE for chromosomal translocation Bollati et al. (2009)
Nerve tumor L1 NR NE NR NR Feber et al. (2011)
Neuroendocrine tumor Alu NR NE PE PE for TSG methylation Choi et al. (2007)
L1 NR NE PE PE for chromosomal alteration and gene methylation Choi et al. (2007)
Non-small cell lung cancer (NSCLC) L1 NR SCC > adenocarcinoma (P < 0.001) NR NR Jin et al. (2009)
L1 NR NR PE NR Saito et al. (2010)
Odontogenic tumor L1 NR Ameloblastoma > KCOT (P = 0.001) NR NR Kitkumthorn and Mutirangura (2010)
Ovarian cancer L1 NS NE PE NR (Pattamadilok et al. 2008)
L1 NR NR NR PE with TSG expression Woloszynska-Read et al. (2008)
L1 NR NR NR PE for follow-up patients treated with decitabine (P < 0.001) Fang et al. (2010)
L1 PE NR NR PE for TSG methylation Woloszynska-Read et al. (2011)
Ovarian clear cell carcinoma L1 PE NR NR NR Iramaneerat et al. (2011)
HERV-E PE NR NR NR Iramaneerat et al. (2011)
HERV-K PE NR PE NR Iramaneerat et al. (2011)
Pancreatic cancer L1 NR NR NR PE for MTHFR polymorphisms Matsubayashi et al. (2005)
Prostate cancer L1 PE NR NR NR Santourlidis et al. (1999)
L1 PE NR PE PE with chromosomal aberration Schulz et al. (2002)
L1 PE NR NR NR Kindich et al. (2006)
Alu PE PE NR NR Cho et al. (2007)
L1 PE PE NR NR Cho et al. (2007)
L1 NR NR PE NR Yegnasubramanian et al. (2008)
L1 NR PE NR NR Cho et al. (2009)
Urothelial cancer L1 PE PE NR NR Florl et al. (1999)
L1 PE PE NE NR Neuhausen et al. (2006)
L1 NR NR NR PE for Met oncogene alternate transcript Wolff et al. (2010)
  1. IRS interspersed repetitive sequence, L1 long interspersed nucleotide element-1, NR no report, NS non-significant, PE positive evidence, NE negative evidence, TSG tumor suppressor gene, CIMP CpG island methylator phenotype, MSS microsatellite stable, MSI microsatellite instability, CIN chromosomal instability, SNP single nucleotide polymorphism, DNMT3B DNA methyltransferase-3B, HNPCC hereditary nonpolyposis colorectal cancer, MM multiple myeloma, HCC hepatocellular carcinoma, SCC squamous cell carcinoma, KCOT keratocystic odontogenic tumor, HERV-E human endogenous retrovirus E, HERV-K human endogenous retrovirus K, MTHFR methylenetetrahydrofolate reductase