Skip to main content

Table 2 Interspersed repetitive sequence hypomethylation and cellular, molecular phenotype

From: Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications

Cancer

IRS

Cellular phenotype

Molecular association

Reference

Higher clinical stage

Poorer histological grade

Survival

Cervical cancer

L1

NR

PE

NR

NR

Shuangshoti et al. (2007)

Cholangiocarcinoma

L1

NR

PE

NR

PE for CIMP and TSG mutation

Kim et al. (2009a)

Colorectal cancer

L1

NR

PE

NR

NR

Chalitchagorn et al. (2004)

L1

NR

NR

NR

PE for MSS

Matsuzaki et al. (2005)

L1

NR

NR

NR

PE for MSI and CIN

Deng et al. (2006)

L1

NR

NR

NR

NE for MSI

Estecio et al. (2007)

L1

PE

PE in mucinous histology

NR

NE for MSI and TSG mutation

Iacopetta et al. (2007)

L1

NR

NR

NR

NE for MSI and CIMP

Ogino et al. (2008a)

PE for chromosomal alteration in non-MSI tumor

L1

NR

NR

PE

NR

Ogino et al. (2008b)

L1

NR

NR

NR

NE for SNPSs in one-carbon pathway genes.

Hazra et al. (2010)

L1

NR

NR

NR

LINE-1 methylation level correlated between synchronous cancer pairs from the same individuals.

Nosho et al. (2009a)

L1

NR

NR

NR

NE for DNMT3B- positive tumors

Nosho et al. (2009b)

L1

NR

NR

NR

PE for CIMP

An et al. (2010)

L1

NR

NR

PE in proximal colon cancer NE in distal colon cancer

NR

Ahn et al. (2010)

L1

NR

NR

PE

PE for MSI, CIMP, CIN, TSG mutation and TSG expression

Baba et al. (2010)

L1

NR

NR

NR

NE for MSI and methylation index

Goel et al. (2010)

PE for MSS HNPCC

L1

NR

PE

NR

NR

Ibrahim et al. (2011)

L1

NR

NR

PE

NE for MSI and CIMP

Kawakami et al. (2011)

Alu, L1

NE

PE

NR

NR

Kwon et al. (2010)

Ependymoma

Alu

NR

PE

NR

NR

Xie et al. (2010)

Gastric cancer

Alu

NR

PE

NR

NR

Park et al. (2009)

L1

NR

PE

NR

NR

Park et al. (2009)

L1

NR

NR

NR

PE for folate metabolizing gene polymorphisms

Hou et al. (2010)

Gastrointestinal stromal cancer

L1

PE

NR

NR

NR

Igarashi et al. (2010)

Head and neck cancer

L1

PE

NR

NR

NR

Smith et al. (2007)

L1

NR

NR

PE especially HPV 16 negative SCC

NR

Furniss et al. (2008)

L1

NS

NS

NR

NR

Subbalekha et al. (2009)

Hepatocellular carcinoma

L1

PE

PE

NR

NR

Tangkijvanich et al. (2007)

Alu

NE

PE

NR

NR

Lee et al. (2009)

L1

PE

PE

NR

NR

Lee et al. (2009)

L1

NR

PE

NR

NR

Kim et al. (2009b)

L1

NR

NR

PE

NR

Formeister et al. (2010)

Multiple myeloma (MM)

Alu

NR

PE

NR

NE for hyperdiploid MM

Bollati et al. (2009)

L1

NR

PE

NR

PE for chromosomal translocation

Bollati et al. (2009)

Nerve tumor

L1

NR

NE

NR

NR

Feber et al. (2011)

Neuroendocrine tumor

Alu

NR

NE

PE

PE for TSG methylation

Choi et al. (2007)

L1

NR

NE

PE

PE for chromosomal alteration and gene methylation

Choi et al. (2007)

Non-small cell lung cancer (NSCLC)

L1

NR

SCC > adenocarcinoma (P < 0.001)

NR

NR

Jin et al. (2009)

L1

NR

NR

PE

NR

Saito et al. (2010)

Odontogenic tumor

L1

NR

Ameloblastoma > KCOT (P = 0.001)

NR

NR

Kitkumthorn and Mutirangura (2010)

Ovarian cancer

L1

NS

NE

PE

NR

(Pattamadilok et al. 2008)

L1

NR

NR

NR

PE with TSG expression

Woloszynska-Read et al. (2008)

L1

NR

NR

NR

PE for follow-up patients treated with decitabine (P < 0.001)

Fang et al. (2010)

L1

PE

NR

NR

PE for TSG methylation

Woloszynska-Read et al. (2011)

Ovarian clear cell carcinoma

L1

PE

NR

NR

NR

Iramaneerat et al. (2011)

HERV-E

PE

NR

NR

NR

Iramaneerat et al. (2011)

HERV-K

PE

NR

PE

NR

Iramaneerat et al. (2011)

Pancreatic cancer

L1

NR

NR

NR

PE for MTHFR polymorphisms

Matsubayashi et al. (2005)

Prostate cancer

L1

PE

NR

NR

NR

Santourlidis et al. (1999)

L1

PE

NR

PE

PE with chromosomal aberration

Schulz et al. (2002)

L1

PE

NR

NR

NR

Kindich et al. (2006)

Alu

PE

PE

NR

NR

Cho et al. (2007)

L1

PE

PE

NR

NR

Cho et al. (2007)

L1

NR

NR

PE

NR

Yegnasubramanian et al. (2008)

L1

NR

PE

NR

NR

Cho et al. (2009)

Urothelial cancer

L1

PE

PE

NR

NR

Florl et al. (1999)

L1

PE

PE

NE

NR

Neuhausen et al. (2006)

L1

NR

NR

NR

PE for Met oncogene alternate transcript

Wolff et al. (2010)

  1. IRS interspersed repetitive sequence, L1 long interspersed nucleotide element-1, NR no report, NS non-significant, PE positive evidence, NE negative evidence, TSG tumor suppressor gene, CIMP CpG island methylator phenotype, MSS microsatellite stable, MSI microsatellite instability, CIN chromosomal instability, SNP single nucleotide polymorphism, DNMT3B DNA methyltransferase-3B, HNPCC hereditary nonpolyposis colorectal cancer, MM multiple myeloma, HCC hepatocellular carcinoma, SCC squamous cell carcinoma, KCOT keratocystic odontogenic tumor, HERV-E human endogenous retrovirus E, HERV-K human endogenous retrovirus K, MTHFR methylenetetrahydrofolate reductase