Virus | Viral protein | Epigenetic interaction |
---|---|---|
HPV | E7 | Binds DNMT1 and stimulates DNA methyltransferase activity |
Binds HDACs and Mi2 subunit of Nurd ATP-dependent remodeling complex | ||
Induces KMD6A and KDM6B histone demethylase expression | ||
Induces expression of histone methyltransferase EZH2 | ||
E6 | Interacts with p300/CBP and inhibits HAT activity | |
EBV | LMP1 | Activates DNMTs 1, 3a, and 3b |
EBNA2 | Interacts with p300 and activates transcription | |
EBNA3c | Binds HDACs | |
KSHV | LANA | Activates DNMT3a |
Interacts with SUV39H1, MeCP2, and mSin3 | ||
vIRFs | Binds p300/CBP and inhibits HAT activity | |
HBV | HBx | Activates DNMT1 |
Regulates the expression of DNMT3a and DNMT3b | ||
Interacts with p300/CBP | ||
Interacts with HDAC | ||
Adenovirus | E1A | Binds DNMT1 and stimulates DNA methyltransferase activity |
Binds p300/CBP, TRRAP/GCN5, and PCAF HAT complexes | ||
Binds to p400 and promotes the formation of a Myc–p400 complex at Myc-target gene promoters | ||
E4ORF3 | Stimulates de novo H3K9me3 heterochromatin formation specifically at p53 target promoters | |
HTLV-1 | Tax | Interacts with p300/CBP to repress transcription |
Binds BRG1 subunit of chromatin-remodeling complexes |