Table 1 Classification of human histone deacetylases
Class | Human HDAC | Yeast HDAC | Co-factor | Compartment | Tissue distribution |
|---|---|---|---|---|---|
I | HDACs 1, 2, 3 and 8 | RPD3 | Zn | Mostly nuclear | Ubiquitous |
IIa | HDACs 4, 5, 7 and 9 | HDA1 | Zn | Nuclear and cytoplasmic | Heart: HDAC4, 5, 7 smooth muscle: HDAC4, 5, 7, 9 brain: HDAC4, 5, 9 placenta, pancreas: HDAC 7 |
IIb | HDACs 6 and 10 | HDA1 | Zn | Cytoplasmic | Kidney, liver: HDAC 6, 10 pancreas, heart: HDAC 6 spleen: HDAC10 |
III | SIRT 1–7 | SIR2 | NAD+ | Nuclear (1,6,7), mitochondrial (3,4,5), cytoplasmic (2) | See (Dali-Youcef et al. 2007) for a comprehensive overview |
IV | HDAC 11 | Â | Zn | Nuclear and cytoplasmic | Heart, smooth muscle, kidney, brain |